Description

Methyl 2'-Fluoro-1,1'-Biphenyl-4-Carboxylate is a high-purity fluorinated biphenyl derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in the precise introduction of fluorine and ester functionalities, which are pivotal for modulating the physicochemical and biological properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries engaged in developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the fluorine atom enhances bioactivity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated biphenyl cores for high-performance liquid crystal displays (LCDs).
• Organic Electronic Materials: Employed in the development of organic semiconductors and charge-transport materials for OLEDs and photovoltaic cells.
• Chemical Research & Development: A versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Cross-Coupling Reactions: Functions as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.

Basic Information

Product Name	Methyl 2'-Fluoro-1,1'-Biphenyl-4-Carboxylate
CAS No.	80254-85-9
Molecular Formula	C14H11FO2
Molecular Weight	230.24 g/mol
Synonyms	2'-Fluorobiphenyl-4-carboxylic acid methyl ester; Methyl 2-fluorobiphenyl-4-carboxylate; 4-(Methoxycarbonyl)-2'-fluorobiphenyl; 2'-Fluoro-4-(methoxycarbonyl)biphenyl; 2'-Fluoro[1,1'-biphenyl]-4-carboxylic acid, methyl ester; Biphenyl-4-carboxylic acid, 2'-fluoro-, methyl ester; Methyl 4-(2-fluorophenyl)benzoate
EINECS	Contact for details

Quality Control

Our Methyl 2'-Fluoro-1,1'-Biphenyl-4-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.