Description

L-Glutamine (α-15N) is a stable isotope-labeled analog of the essential amino acid L-glutamine, where the α-amino nitrogen atom is enriched with the 15N isotope. This product is critical for advanced research and development, enabling precise metabolic tracing and quantification in complex biological systems using techniques like NMR spectroscopy and mass spectrometry. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers in the fields of metabolomics, proteomics, and drug discovery.

Application

• Metabolic Pathway Tracing: Used as a stable isotope tracer in NMR and LC-MS studies to investigate glutamine metabolism in cancer cells, immune cells, and neurological systems.
• Quantitative Proteomics & Metabolomics: Serves as an internal standard for the accurate mass spectrometric quantification of glutamine and its metabolites in biological samples.
• Drug Discovery & Development: Employed in preclinical research to study the mechanism of action of drugs targeting glutaminase or glutamine metabolism.
• Biochemical Research: Essential for enzymatic studies, protein synthesis research, and investigating nitrogen metabolism in plants and microorganisms.
• Diagnostic Assay Development: Used in the formulation of calibration standards and controls for clinical diagnostic tests measuring glutamine levels.

Basic Information

Product Name	L-Glutamine (α-15N)
CAS No.	80143-57-3
Molecular Formula	C5H1015N2O3
Molecular Weight	147.13 g/mol (for 15N1)
Synonyms	(2S)-2-Amino-4-carbamoylbutanoic-α-15N acid; L-Glutamine-α-15N; Glutamine-α-15N; (S)-2,5-Diamino-5-oxopentanoic-α-15N acid; L-Gln-α-15N; 15N-L-Glutamine (α-labeled); Stable Isotope Labeled L-Glutamine
EINECS	Contact for details

Quality Control

Our L-Glutamine (α-15N) is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (Atom % 15N), chemical purity, and analytical results from NMR, HPLC, and MS. We adhere to cGMP principles for traceability and documentation, ensuring reliable and reproducible performance in your critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Confirms 15N labeling at alpha position
Isotopic Enrichment (Atom % 15N)	≥ 98%
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Optical Rotation	[α]D20: +6.0° to +8.0° (c=2 in H2O)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.