Description

n-Acetylleukotriene D4 is a chemically modified derivative of the potent inflammatory mediator leukotriene D4. This compound is a critical biochemical tool for researchers investigating the complex pathways of inflammation, allergy, and asthma. It is primarily utilized in pharmaceutical R&D, academic research, and diagnostic assay development to study receptor binding, signal transduction, and the development of novel therapeutic agents targeting the cysteinyl leukotriene pathway.

Application

• Biochemical Research Standard: Serves as a high-purity reference standard in analytical methods like HPLC and LC-MS for quantifying leukotriene metabolites in biological samples.
• Pharmacological Studies: Used as a key ligand in receptor binding assays and functional studies to characterize and antagonize the CysLT1 receptor.
• Inflammation & Allergy Research: A vital tool for modeling inflammatory cascades in cell-based assays to understand mechanisms underlying asthma, allergic rhinitis, and anaphylaxis.
• Drug Discovery & Development: Employed in high-throughput screening (HTS) campaigns and lead optimization phases to identify and evaluate new anti-inflammatory drug candidates.
• Diagnostic Development: Used in the development and calibration of immunoassays (e.g., ELISA) for detecting leukotriene-related biomarkers in clinical research settings.

Basic Information

Product Name	n-Acetylleukotriene D4
CAS No.	80115-94-2
Molecular Formula	C25H39NO7S
Molecular Weight	497.65 g/mol
Synonyms	N-Acetyl-LTD4; Leukotriene D4, N-acetyl-; N-Acetylcysteinylglycyl-leukotriene E4; 5(S)-Hydroxy-6(R)-S-cysteinylglycyl-7,9-trans-11,14-cis-eicosatetraenoic Acid N-Acetate; Acetylated Leukotriene D4; LTD4 Acetamide; N-Acetyl Leukotriene D4
EINECS	Contact for details

Quality Control

Every batch of n-Acetylleukotriene D4 is manufactured and analyzed under strict quality protocols to ensure identity, purity, and consistency suitable for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data (HPLC purity, identity confirmation) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.