Description

n-(Deoxyguanosin-C(8)-Yl)-4-Aminoquinoline 1-Oxide is a specialized biochemical compound, a guanine adduct formed with 4-nitroquinoline 1-oxide, a known mutagen. This compound is of significant value in research for studying DNA damage, mutagenesis, and carcinogenesis mechanisms. It is primarily utilized by researchers and scientists in the fields of toxicology, molecular biology, and cancer research for analytical standards and investigative studies.

Application

• Biomarker Research: Used as a reference standard for the detection and quantification of specific DNA adducts in biological samples.
• Toxicology Studies: Essential for investigating the metabolic activation and DNA-binding properties of nitroquinoline oxide derivatives.
• Mechanistic Cancer Research: Employed to understand the molecular mechanisms of chemical carcinogenesis and DNA repair pathways.
• Analytical Method Development: Serves as a critical standard in HPLC, LC-MS, and other chromatographic techniques for method validation.
• Genotoxicity Testing: Used in studies to assess the DNA-damaging potential of related compounds and environmental agents.
• Academic and Pharmaceutical R&D: Supports fundamental research in universities and drug discovery programs focused on oncology and DNA damage response.

Basic Information

Item	Details
Product Name	n-(Deoxyguanosin-C(8)-Yl)-4-Aminoquinoline 1-Oxide
CAS No.	80038-04-6
Molecular Formula	C19H19N7O5
Molecular Weight	425.40 g/mol
Synonyms	4-AQO-deoxyguanosine adduct; C8-(4-Aminoquinoline 1-oxide)-2'-deoxyguanosine; N-(Deoxyguanosin-8-yl)-4-aminoquinoline 1-oxide; 4-NQO-Guanine Adduct; 4-HAQO-dG; DNA Adduct of 4-Nitroquinoline 1-Oxide; Guanine-4-AQO Adduct
EINECS	Contact for details

Quality Control

Our n-(Deoxyguanosin-C(8)-Yl)-4-Aminoquinoline 1-Oxide is produced and handled under strict quality protocols to ensure the integrity required for sensitive research applications. Each batch is characterized using advanced analytical techniques, including NMR and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, chromatographic data, and storage recommendations is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.