Description

Dothiepin Hcl CAS NO 897-15-4 is the hydrochloride salt of dothiepin, a tricyclic antidepressant (TCA) compound. This active pharmaceutical ingredient (API) is critical for the formulation of effective antidepressant medications, offering therapeutic benefits for the management of depressive disorders. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of central nervous system (CNS) therapeutics.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of antidepressant medications.
• Reference Standard: Serves as a high-purity standard for analytical testing, quality control, and method validation in pharmaceutical laboratories.
• Clinical Research: Utilized in preclinical and clinical studies investigating the efficacy and mechanisms of tricyclic antidepressants.
• Formulation Development: Used in R&D for developing new dosage forms such as tablets, capsules, or controlled-release formulations.
• Biochemical Research: Employed in studies of neurotransmitter reuptake inhibition, particularly of serotonin and norepinephrine.

Basic Information

Item	Detail
Product Name	Dothiepin Hcl
CAS No.	897-15-4
Molecular Formula	C19H21NS•HCl
Molecular Weight	331.90 g/mol
Synonyms	Dothiepin Hydrochloride; Dosulepin Hydrochloride; Prothiaden; Dothep; ICI-58,834; 11-(3-Dimethylaminopropylidene)-6H-dibenzo[b,e]thiepin Hydrochloride; 3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine Hydrochloride
EINECS	Contact for details

Quality Control

Our Dothiepin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.