Description

Nortriptyline Hydrochloride is a tricyclic antidepressant (TCA) compound, widely recognized for its therapeutic efficacy in managing major depressive disorders. Its primary commercial value lies in its role as a critical active pharmaceutical ingredient (API) for the formulation of various antidepressant medications. This product is essential for pharmaceutical manufacturers, research institutions, and chemical suppliers serving the global life sciences sector.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of antidepressant tablets, capsules, and other dosage forms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Biochemical Research: Utilized in neuroscience and pharmacological studies to investigate the mechanisms of tricyclic antidepressants and monoamine reuptake inhibition.
• Formulation Development: Employed in R&D for developing new drug delivery systems and generic pharmaceutical products.
• Clinical Trial Material: Supplied as a key component for investigational new drug (IND) applications and clinical studies.

Basic Information

Product Name	Nortriptyline Hydrochloride
CAS No.	894-71-3
Molecular Formula	C19H21N•HCl
Molecular Weight	299.84 g/mol
Synonyms	Nortriptyline HCl; 10,11-Dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-δ5,γ-propylamine Hydrochloride; 5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene Hydrochloride; Desmethylamitriptyline Hydrochloride; Aventyl Hydrochloride (former brand name); Pamelor (former brand name); Allegron; Nortrilen.
EINECS	213-952-5

Quality Control

Our Nortriptyline Hydrochloride is manufactured and tested under a strict quality management system. We ensure compliance with relevant pharmacopeial standards, including USP and EP monographs where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, providing full traceability and quality assurance for our B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.