Description

Homatropine CAS NO 87-00-3 is a synthetic anticholinergic alkaloid, chemically related to atropine. It is a critical pharmaceutical intermediate and active pharmaceutical ingredient (API) valued for its potent mydriatic and cycloplegic properties. This compound is essential for manufacturers in the ophthalmic and pharmaceutical industries, where it is used to produce diagnostic and therapeutic agents.

Application

• Ophthalmic Solutions: Primary use as an active ingredient in eye drops for pupil dilation (mydriasis) and paralysis of accommodation (cycloplegia) during eye examinations.
• Pharmaceutical API: Serves as a key starting material or intermediate in the synthesis of more complex anticholinergic and spasmolytic medications.
• Research & Development: Utilized in biochemical and pharmacological research to study muscarinic acetylcholine receptor antagonists.
• Reference Standards: Supplied as a high-purity certified reference material (CRM) for quality control and analytical method development in pharmaceutical labs.
• Veterinary Medicine: Applied in veterinary ophthalmic preparations for diagnostic procedures in animals.

Basic Information

Product Name	Homatropine
CAS No.	87-00-3
Molecular Formula	C16H21NO3
Molecular Weight	275.34 g/mol
Synonyms	Homatropine Hydrobromide (common salt); Mandelyltropine; Tropine mandelate; (1R,3r,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 2-hydroxy-2-phenylacetate; DL-Homatropine; Tropyl mandelate
EINECS	201-722-7

Quality Control

Our Homatropine is manufactured and tested to meet stringent pharmaceutical-grade standards. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) that includes data for identity, purity, and related substances. We adhere to cGMP principles, and our quality system supports compliance with major pharmacopoeial standards such as USP and EP. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and in original packaging until use to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.