Description

Abacavir is a potent synthetic carbocyclic nucleoside analog, widely recognized for its critical role in antiretroviral therapy. Its primary value lies in its high efficacy as a reverse transcriptase inhibitor, making it a cornerstone component in modern combination treatments. This active pharmaceutical ingredient is essential for manufacturers in the global pharmaceutical industry, particularly those developing and producing medications for HIV-1 infection management.

Application

• Pharmaceutical Active Ingredient (API): The primary and most significant application is as the key active component in fixed-dose combination antiretroviral tablets and oral solutions for treating Human Immunodeficiency Virus Type 1 (HIV-1) infection.
• Antiretroviral Drug Formulation: Used in the synthesis and commercial production of branded and generic medications, such as Ziagen®, and in combination drugs like Epzicom® (abacavir sulfate and lamivudine) and Trizivir® (abacavir, lamivudine, and zidovudine).
• Research & Development: Serves as a critical reference standard and building block in virology and medicinal chemistry research for developing new nucleoside analog therapies and studying drug resistance mechanisms.
• Preclinical & Clinical Trial Material: Supplied as a high-purity compound for use in pharmacological studies, toxicology assessments, and various phases of clinical trials for new HIV treatment regimens.

Basic Information

Product Name	Abacavir
CAS No.	783292-37-5
Molecular Formula	C14H18N6O
Molecular Weight	286.33 g/mol
Synonyms	Abacavir (base); (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; 1592U89; Ziagen (Brand Name); ABC; Cyclopropavir; Abacavir Sulfate (salt form); ATC Code: J05AF06
EINECS	Contact for details

Quality Control

Our Abacavir is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical application development. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling to ensure consistency and reliability. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed-upon specifications. We support development needs across various regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.