Description

3-Chloro-2-Fluorobenzoic Acid Methyl Ester is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound serves as a versatile intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated motifs into their target structures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the chloro-fluoro substitution pattern enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in liquid crystal displays (LCDs), improving dielectric anisotropy and thermal stability.
• Organic Electronic Materials: Intermediate for the synthesis of fluorinated organic semiconductors and charge-transport materials used in OLEDs and photovoltaic cells.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl systems.
• Chemical Research & Development: A valuable reagent for method development and exploring new fluorination and functionalization chemistries in academic and industrial R&D labs.

Basic Information

Item	Details
Product Name	3-Chloro-2-Fluorobenzoic Acid Methyl Ester
CAS No.	773874-05-8
Molecular Formula	C8H6ClFO2
Molecular Weight	188.58 g/mol
Synonyms	Methyl 3-Chloro-2-fluorobenzoate; 3-Chloro-2-fluorobenzoic acid methyl ester; Benzoic acid, 3-chloro-2-fluoro-, methyl ester; 2-Fluoro-3-chlorobenzoic acid methyl ester; Methyl 2-fluoro-3-chlorobenzoate; 773874-05-8; 3-Chloro-2-fluorobenzoate methyl ester
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluorobenzoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.