Description

Methyl 3-Chloro-2-Fluoro-5-(Trifluoromethyl)Benzoate is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique substitution pattern, which facilitates the introduction of multiple halogen and trifluoromethyl groups into complex molecular architectures. It is primarily utilized by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for liquid crystals and advanced polymers, contributing to the development of materials with specific optical or electronic properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to construct complex, multi-functional aromatic systems.

Basic Information

Product Name	Methyl 3-Chloro-2-Fluoro-5-(Trifluoromethyl)Benzoate
CAS No.	773874-03-6
Molecular Formula	C9H5ClF4O2
Molecular Weight	256.58 g/mol
Synonyms	Benzoic acid, 3-chloro-2-fluoro-5-(trifluoromethyl)-, methyl ester; Methyl 3-chloro-2-fluoro-5-(trifluoromethyl)benzoate; 3-Chloro-2-fluoro-5-(trifluoromethyl)benzoic acid methyl ester; Methyl 3-chloro-2-fluoro-alpha,alpha,α-trifluoro-m-toluate
EINECS	Contact for details

Quality Control

Our production of Methyl 3-Chloro-2-Fluoro-5-(Trifluoromethyl)Benzoate adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality management system is designed to meet the exacting standards required for cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.