Description

2-Hydroxy-3-Trifluoromethoxy-Benzoic Acid is a high-value fluorinated aromatic building block characterized by its unique combination of a carboxylic acid, a phenolic hydroxyl group, and a trifluoromethoxy substituent. This compound matters for its role in advanced organic synthesis, where its distinct electronic properties are leveraged to modulate the biological activity, metabolic stability, and lipophilicity of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring fluorinated motifs for enhanced bioavailability and target binding.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve environmental stability and efficacy.
• Ligand and Catalyst Development: Serves as a precursor for designing specialized chelating ligands or organocatalysts used in asymmetric synthesis and metal complexation.
• Material Science Research: Employed in the synthesis of functionalized monomers for specialty polymers, coatings, or liquid crystals, imparting specific chemical resistance or optical properties.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological processes, leveraging fluorine as an NMR-active marker.

Basic Information

Product Name	2-Hydroxy-3-Trifluoromethoxy-Benzoic Acid
CAS No.	773873-50-0
Molecular Formula	C8H5F3O4
Molecular Weight	222.12 g/mol
Synonyms	3-Trifluoromethoxysalicylic Acid; 2-Hydroxy-3-(trifluoromethoxy)benzoic Acid; Benzoic acid, 2-hydroxy-3-(trifluoromethoxy)-; Salicylic acid, 3-trifluoromethoxy-; 3-(Trifluoromethoxy)salicylic Acid
EINECS	Contact for details

Quality Control

Our production of 2-Hydroxy-3-Trifluoromethoxy-Benzoic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF for moisture content, to ensure consistency and compliance with customer specifications. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Due to its acidic nature, handle with appropriate engineering controls and personal protective equipment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.