Description

Benzoic Acid, 5-Chloro-2-(Trifluoromethyl)-, Ethyl Ester is a high-value fluorinated aromatic ester building block, distinguished by its unique trifluoromethyl and chloro substituents which confer enhanced lipophilicity and metabolic stability. This compound is critical for advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals where the introduction of fluorine atoms is a key design strategy. It serves as an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sophisticated, multi-functional aromatic systems into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially in medicinal chemistry programs targeting CNS, anti-inflammatory, and anti-infective agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a fluorinated building block for electronic chemicals used in display technologies, contributing to improved dielectric anisotropy and stability.
• Organic Synthesis & Catalysis: Employed as a versatile reagent in cross-coupling reactions, esterifications, and as a precursor for more complex fluorinated compounds in academic and industrial R&D.
• Polymer Modification: Acts as a monomer or modifier to introduce fluorine into polymer chains, enhancing material properties like chemical resistance, thermal stability, and surface characteristics.

Basic Information

Product Name	Benzoic Acid, 5-Chloro-2-(Trifluoromethyl)-, Ethyl Ester
CAS No.	773135-63-0
Molecular Formula	C10H8ClF3O2
Molecular Weight	252.62 g/mol
Synonyms	Ethyl 5-Chloro-2-(trifluoromethyl)benzoate; 5-Chloro-α,α,α-trifluoro-o-toluic Acid Ethyl Ester; 2-(Trifluoromethyl)-5-chlorobenzoic Acid Ethyl Ester; Benzoic acid, 5-chloro-2-(trifluoromethyl)-, ethyl ester; Ethyl 5-chloro-α,α,α-trifluoro-o-toluate; o-Toluic acid, 5-chloro-α,α,α-trifluoro-, ethyl ester
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 5-Chloro-2-(Trifluoromethyl)-, Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to guarantee batch-to-batch consistency and support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.