Description

Benzoic Acid, 3-(Difluoromethoxy)-, Ethyl Ester is a specialized fluorinated benzoate derivative, a high-value intermediate designed for advanced chemical synthesis. This compound matters for its role in introducing the difluoromethoxy moiety, a key structural feature known to enhance metabolic stability and lipophilicity in target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluoromethoxy group can improve biological activity and environmental profile.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and liquid crystals with unique optical or electronic properties.
• Chemical Biology & Proteomics: Employed as a probe or linker in the design of enzyme inhibitors and activity-based protein profiling (ABPP) reagents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring fluorinated aromatic compounds.

Basic Information

Product Name	Benzoic Acid, 3-(Difluoromethoxy)-, Ethyl Ester
CAS No.	773135-28-7
Molecular Formula	C10H10F2O3
Molecular Weight	216.18 g/mol
Synonyms	Ethyl 3-(Difluoromethoxy)benzoate; 3-(Difluoromethoxy)benzoic Acid Ethyl Ester; Benzoic acid, 3-(difluoromethoxy)-, ethyl ester; Ethyl m-(Difluoromethoxy)benzoate; 3-Difluoromethoxy-benzoic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 3-(Difluoromethoxy)-, Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its sensitivity to light, the container should be opaque or stored in a dark cabinet.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.