Description

2-Fluoro-3-Trifluoromethylbenzoic Acid Ethyl Ester is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound is prized for its unique trifluoromethyl and fluorine substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated components for electronic display materials, improving dielectric anisotropy and stability.
• Functional Material Development: Employed in creating specialty polymers, coatings, and additives that require specific surface energy and chemical resistance properties.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig aminations for constructing complex biaryl systems.

Basic Information

Product Name	2-Fluoro-3-Trifluoromethylbenzoic Acid Ethyl Ester
CAS No.	773134-92-2
Molecular Formula	C10H7F4O2
Molecular Weight	236.16 g/mol
Synonyms	Ethyl 2-Fluoro-3-(trifluoromethyl)benzoate; Benzoic acid, 2-fluoro-3-(trifluoromethyl)-, ethyl ester; 2-Fluoro-α,α,α-trifluoro-m-toluic acid ethyl ester; Ethyl 2-fluoro-α,α,α-trifluoro-m-toluate; 3-Trifluoromethyl-2-fluorobenzoic acid ethyl ester; ETFTB; 2-F-3-CF3-Bz-OEt
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-Trifluoromethylbenzoic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.