Description

Ethyl 2,4,6-Trifluorobenzoate is a high-purity fluorinated aromatic ester, a key synthetic intermediate prized for its trifluoromethyl-substituted benzoate structure. This compound is essential for introducing the trifluoromethylphenyl moiety into target molecules, significantly influencing their lipophilicity, metabolic stability, and binding affinity. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of advanced active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for creating fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Advanced Polymer Modification: Incorporated into polymer chains to impart specific properties like chemical resistance, thermal stability, or altered refractive index.
• Organic Synthesis & Catalysis Research: Employed in cross-coupling reactions (e.g., Suzuki, Stille) and as a ligand precursor in organometallic chemistry and catalysis development.
• Fluorine Chemistry Reference Standard: Utilized as a pure standard in analytical method development and quality control for fluorinated compounds.

Basic Information

Product Name	Ethyl 2,4,6-Trifluorobenzoate
CAS No.	773134-91-1
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	Ethyl 2,4,6-Trifluorobenzoate; Benzoic acid, 2,4,6-trifluoro-, ethyl ester; 2,4,6-Trifluorobenzoic acid ethyl ester; Ethyl 2,4,6-trifluorobenzoate; Ethyl 2,4,6-Trifluorobenzoate (CAS 773134-91-1); 773134-91-1; Ethyl α,α,α-Trifluorobenzoate (substituted)
EINECS	Contact for details

Quality Control

Our Ethyl 2,4,6-Trifluorobenzoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.