Description

2-Iodo-3-(Trifluoromethyl)Benzoic Acid is a high-value, multi-functional aromatic building block characterized by its unique combination of iodine and trifluoromethyl substituents. This compound is essential for advanced organic synthesis, enabling the introduction of both halogen and fluorine motifs critical for modulating the physicochemical properties of target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, cross-coupling reactions, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery and development, particularly for candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to form new carbon-carbon bonds.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore fluorinated and iodinated analogs of lead compounds.
• Chemical Research: A versatile reagent for academic and industrial R&D in synthetic organic and organofluorine chemistry.

Basic Information

Product Name	2-Iodo-3-(Trifluoromethyl)Benzoic Acid
CAS No.	766473-89-6
Molecular Formula	C8H4F3IO2
Molecular Weight	316.02 g/mol
Synonyms	3-(Trifluoromethyl)-2-iodobenzoic Acid; 2-Iodo-α,α,α-trifluoro-m-toluic Acid; Benzoic acid, 2-iodo-3-(trifluoromethyl)-; 766473-89-6; 2-Iodo-3-trifluoromethylbenzoic acid; m-Trifluoromethyl-2-iodobenzoic Acid
EINECS	Contact for details

Quality Control

Every batch of 2-Iodo-3-(Trifluoromethyl)Benzoic Acid is manufactured and tested under strict quality management protocols to ensure consistency and reliability for your critical syntheses. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residue on Ignition	<0.1%
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.