Description

2-Fluoro-3-Tolylboronic Acid is a high-purity organoboron compound, specifically a boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific fluorinated aromatic structures.
• Material Science Research: Building block for creating organic electronic materials, such as ligands for catalysts or monomers for specialty polymers.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and diagnostic agents where the fluorine atom and boronic acid group offer unique reactivity and binding properties.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the 2-fluoro-3-methylphenyl moiety into target molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical companies for use in custom synthesis projects and scale-up production.

Basic Information

Product Name	2-Fluoro-3-Tolylboronic Acid
CAS No.	762287-58-1
Molecular Formula	C7H8BFO2
Molecular Weight	153.95 g/mol
Synonyms	(2-Fluoro-3-methylphenyl)boronic acid; 3-Methyl-2-fluorobenzeneboronic acid; 2-Fluoro-m-tolylboronic acid; Boronic acid, B-(2-fluoro-3-methylphenyl)-; 2-Fluoro-3-methylbenzeneboronic acid; 2-Fluoro-3-methylphenylboronic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-3-Tolylboronic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high standards required for sensitive cross-coupling applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.