Description

Di-T-Butyl-1-[3-(N,n-Dimethylamino)Propyl]Phosphine is a specialized organophosphorus compound featuring a sterically hindered phosphine ligand with a pendant tertiary amine group. This unique bifunctional structure makes it a highly valuable and versatile ligand in advanced catalytic transformations, particularly in cross-coupling reactions and asymmetric synthesis. It is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel synthetic routes and optimize catalytic processes for high-value intermediates and active ingredients.

Application

• As a ligand in homogeneous catalysis, particularly for palladium- and nickel-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig amination).
• Utilized in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs) requiring high selectivity and yield.
• Employed in asymmetric hydrogenation and other chiral transformations for the production of enantiomerically pure compounds.
• Acts as a precursor or additive in the preparation of advanced materials, such as metal-organic frameworks (MOFs) or catalysts.
• Used in academic and industrial R&D for developing new catalytic methodologies and exploring novel reaction pathways.
• Applied in the manufacture of agrochemicals and other specialty chemicals where efficient metal catalysis is critical.

Basic Information

Product Name	Di-T-Butyl-1-[3-(N,n-Dimethylamino)Propyl]Phosphine
CAS No.	758699-75-1
Molecular Formula	C13H30NP
Molecular Weight	231.36 g/mol
Synonyms	Di-tert-Butyl(3-(dimethylamino)propyl)phosphine; 1-[3-(Dimethylamino)propyl]-di-tert-butylphosphine; (3-(Dimethylamino)propyl)di-tert-butylphosphine; DTBPAP; Di-t-butyl(3-(dimethylamino)propyl)phosphine; N,N-Dimethyl-3-(di-tert-butylphosphino)propylamine; Phosphine, [3-(dimethylamino)propyl]di-tert-butyl-
EINECS	Contact for details

Quality Control

Our production of Di-T-Butyl-1-[3-(N,n-Dimethylamino)Propyl]Phosphine adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity, which is critical for catalytic performance. Each lot is characterized by advanced analytical techniques including NMR, GC, and HPLC. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this material must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 95.0%
Purity (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.