Description

(R)-5,6,6A,7-Tetrahydro-1,2-Dimethoxy-6,6-Dimethyl-4H-Dibenzo[De,G]Quinolinium CAS NO 754919-24-9 is a high-purity, chiral tetrahydroisoquinoline derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or a key pharmacophore in the creation of novel therapeutic agents. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors. Its defined stereochemistry and complex polycyclic structure make it a valuable building block for targeting specific biological pathways.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential central nervous system (CNS) active drugs, alkaloid-based therapeutics, and receptor-targeted molecules.
• Asymmetric Catalysis Research: Employed as a ligand or a substrate in the development and study of novel asymmetric synthetic methodologies.
• Medicinal Chemistry & SAR Studies: Used as a core scaffold for structure-activity relationship (SAR) investigations to optimize potency, selectivity, and pharmacokinetic properties of drug candidates.
• Reference Standard: Serves as an analytical standard for quality control and method development in laboratories manufacturing or researching related compounds.
• Biochemical Research: Utilized in studies investigating enzyme inhibition or receptor binding interactions due to its complex, alkaloid-like structure.
• Process Chemistry Development: Acts as a critical intermediate for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) guidelines for Active Pharmaceutical Ingredient (API) production.

Basic Information

Product Name	(R)-5,6,6A,7-Tetrahydro-1,2-Dimethoxy-6,6-Dimethyl-4H-Dibenzo[De,G]Quinolinium
CAS No.	754919-24-9
Molecular Formula	C21H25NO2
Molecular Weight	323.43 g/mol
Synonyms	(R)-1,2-Dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolinium; (R)-N-Methylcorydine; (R)-Corydine methiodide (common salt form reference); (R)-6,6-Dimethyl-1,2-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolinium; (R)-Tetrahydropalmatine derivative; (R)-THP-Dimethoxy Dimethyl Derivative
EINECS	Contact for details

Quality Control

Our (R)-5,6,6A,7-Tetrahydro-1,2-Dimethoxy-6,6-Dimethyl-4H-Dibenzo[De,G]Quinolinium is manufactured under strict quality control protocols to ensure high chemical and chiral purity suitable for research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development needs with custom synthesis and scale-up services under quality agreements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.