Description

2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine is a high-value, multi-functional boronic ester derivative that serves as a critical synthetic intermediate. Its core value proposition lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and advanced materials synthesis. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-purity building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing the trifluoromethylpyridine moiety, which is prized for its metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the introduction of specific halogenated and fluorinated pyridine structures enhances biological activity.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to efficiently introduce the substituted pyridine ring into more complex molecular systems.
• Chemical Biology & Medicinal Chemistry: Employed in the discovery and optimization of drug candidates, enabling rapid exploration of structure-activity relationships (SAR) around the pyridine core.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical and CDMO (Contract Development and Manufacturing Organization) providers offering bespoke synthesis services.

Basic Information

Item	Detail
Product Name	2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethyl)Pyridine
CAS No.	741709-67-1
Molecular Formula	C12H14BClF3NO2
Molecular Weight	305.50 g/mol
Synonyms	2-Chloro-3-(trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-(Trifluoromethyl)-2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Chloro-5-(pinacolatoboryl)-3-(trifluoromethyl)pyridine; 5-Boronic acid, 2-chloro-3-(trifluoromethyl)pyridine, pinacol ester; (2-Chloro-3-(trifluoromethyl)pyridin-5-yl)boronic acid pinacol ester; CAS 741709-67-1
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. The container should be kept tightly sealed in a dry inert atmosphere to protect the boronic ester functionality from potential hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.