Description

Pnu-282987 (S Enantiomer Free Base) is a high-purity, enantiomerically pure chemical compound used as a key research tool in neuroscience and pharmacology. This compound is specifically valued for its selective activity as a potent and full agonist at the α7 subtype of neuronal nicotinic acetylcholine receptors (nAChRs). It is primarily utilized by pharmaceutical researchers, academic institutions, and R&D laboratories engaged in the study of cognitive function, neuropsychiatric disorders, and the development of novel therapeutic agents targeting the cholinergic system.

Application

• Neuroscience Research: A critical tool for studying the role of α7 nAChRs in synaptic plasticity, learning, and memory.
• Pharmacological Profiling: Used in in vitro and in vivo assays to characterize receptor function and screen for new drug candidates.
• Cognitive Disorder Models: Applied in preclinical research for conditions like Alzheimer's disease, schizophrenia, and attention deficit disorders.
• Signal Transduction Studies: Investigates downstream pathways activated by α7 nAChR stimulation, including calcium signaling.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in related compound synthesis.

Basic Information

Product Name	Pnu-282987 (S Enantiomer Free Base)
CAS No.	737727-12-7
Molecular Formula	C₁₇H₂₅N₃O₂
Molecular Weight	303.40 g/mol
Synonyms	(S)-N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5-chlorothiophene-2-carboxamide; (S)-PNU-282987; PNU 282987 free base; (S)-5-Chloro-N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]thiophene-2-carboxamide; (S)-enantiomer of PNU-282987; α7 nAChR agonist (S-form); PNU282987 (S); AZD0328 related compound
EINECS	Contact for details

Quality Control

Our Pnu-282987 (S Enantiomer Free Base) is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and identity confirmation. We adhere to relevant quality guidelines to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.