Description

trans-2-[2-Oxo-2-(2-Trifluoromethylphenyl)Ethyl]Cyclohexane-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its specific chiral and trifluoromethyl-substituted aromatic structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), where its precise stereochemistry and functional groups enable targeted biological activity. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the bioactivity of the trifluoromethyl group.
• Chemical Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Development: Employed in scaling up synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing specialized fine chemicals for client projects.

Basic Information

Product Name	trans-2-[2-Oxo-2-(2-Trifluoromethylphenyl)Ethyl]Cyclohexane-1-Carboxylic Acid
CAS No.	735274-98-3
Molecular Formula	C₁₆H₁₇F₃O₃
Molecular Weight	314.30 g/mol
Synonyms	2-[2-Oxo-2-[2-(trifluoromethyl)phenyl]ethyl]cyclohexanecarboxylic acid; Cyclohexanecarboxylic acid, 2-[2-oxo-2-[2-(trifluoromethyl)phenyl]ethyl]-; (1R,2R)-rel-2-[2-Oxo-2-[2-(trifluoromethyl)phenyl]ethyl]cyclohexanecarboxylic acid; (1S,2S)-rel-2-[2-Oxo-2-[2-(trifluoromethyl)phenyl]ethyl]cyclohexanecarboxylic acid; 735274-98-3; trans-2-(2-Oxo-2-(2-trifluoromethylphenyl)ethyl)cyclohexane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of trans-2-[2-Oxo-2-(2-Trifluoromethylphenyl)Ethyl]Cyclohexane-1-Carboxylic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthesis. Each lot is analyzed using advanced chromatographic and spectroscopic techniques to confirm identity, purity, and the absence of specified impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment, supporting compliance with internal specifications and customer requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its chemical nature as a strong acid/organic solvent, it should be kept away from incompatible materials such as strong bases and oxidizing agents. Ensure the container is kept upright to prevent leakage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.