Description

trans-2-[2-(2-Fluorophenyl)-2-Oxoethyl]Cyclohexane-1-Carboxylic Acid is a high-purity fluorinated organic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key chiral intermediate in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate a specific fluorinated, ketone-substituted cyclohexane carboxylic acid motif into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and production of potential drug candidates, particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides where the fluorophenyl and carboxylic acid functionalities contribute to biological activity.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Employed in the synthesis of complex fluorinated fragrances, dyes, and other high-value specialty chemicals.
• Academic & Industrial R&D: A valuable compound for methodological studies in organic chemistry, including novel fluorination and cyclization reactions.

Basic Information

Product Name	trans-2-[2-(2-Fluorophenyl)-2-Oxoethyl]Cyclohexane-1-Carboxylic Acid
CAS No.	735274-94-9
Molecular Formula	C15H17FO3
Molecular Weight	264.29 g/mol
Synonyms	2-[(2-Fluorobenzoyl)methyl]cyclohexanecarboxylic acid (trans); trans-2-[(2-Fluorobenzoyl)methyl]cyclohexanecarboxylic acid; (1R,2R)-2-[2-(2-Fluorophenyl)-2-oxoethyl]cyclohexane-1-carboxylic acid; (1S,2S)-2-[2-(2-Fluorophenyl)-2-oxoethyl]cyclohexane-1-carboxylic acid; 735274-94-9; Fluorophenyl Cyclohexane Carboxylic Acid Derivative; 2-(2-Fluorobenzoylethyl)cyclohexanecarboxylic acid
EINECS	Contact for details

Quality Control

Our trans-2-[2-(2-Fluorophenyl)-2-Oxoethyl]Cyclohexane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and cGMP starting material applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled and stored away from strong acids and organic solvents as indicated by its chemical properties. Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans isomer)
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.