Description

(1R,4S) Sertraline Hydrochloride CAS NO 79896-32-5 is the single enantiomer of the widely used selective serotonin reuptake inhibitor (SSRI), representing the pharmacologically active form. This high-purity intermediate is critical for ensuring the efficacy and safety of the final active pharmaceutical ingredient (API) in antidepressant formulations. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in the development and production of enantiomerically pure therapeutics.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Key chiral building block in the synthesis of Sertraline API.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies for new CNS drug candidates.
• Process Chemistry & Optimization: Serves as a reference standard for developing and validating asymmetric synthesis routes.
• Analytical Standard: Employed as a high-purity standard for HPLC, LC-MS, and chiral analysis methods.
• Generic Drug Manufacturing: Essential for producing bioequivalent generic versions of Sertraline-based medications.
• Academic Research: Used in university and institutional studies focusing on neuropharmacology and chiral chemistry.

Basic Information

Product Name	(1R,4S) Sertraline Hydrochloride
CAS No.	79896-32-5
Molecular Formula	C17H17Cl2N•HCl
Molecular Weight	342.69 g/mol
Synonyms	(1S,4R)-Sertraline Hydrochloride; (+)-Sertraline Hydrochloride; (1R-cis)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine Hydrochloride; Zoloft Intermediate; CP-51974-01; L-Sertraline Hydrochloride; Sertraline HCl Enantiomer
EINECS	Contact for details

Quality Control

Our (1R,4S) Sertraline Hydrochloride is manufactured under strict quality management systems. Each batch is tested to meet high-purity standards suitable for pharmaceutical R&D and intermediate use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment to ensure traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.