Description

(1S,4R) Sertraline Hydrochloride is the single enantiomer form of the widely used selective serotonin reuptake inhibitor (SSRI). This high-purity chiral intermediate is critical for pharmaceutical manufacturers requiring precise stereochemistry in their active pharmaceutical ingredient (API) synthesis. It is primarily utilized by advanced pharmaceutical and fine chemical companies engaged in the research, development, and production of enantiomerically pure therapeutics, particularly for central nervous system (CNS) disorders.

Application

• Pharmaceutical API Synthesis: As a key chiral building block for the manufacture of Sertraline and related enantiomerically pure SSRIs.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in regulatory filings.
• Process Research & Development (R&D): Used in route scouting and optimization studies for novel synthetic pathways to chiral pharmaceuticals.
• Asymmetric Synthesis Studies: Valuable intermediate in academic and industrial research focused on stereoselective catalysis and synthesis.
• Generic Drug Manufacturing: Essential for companies producing bioequivalent versions of Sertraline-based medications, ensuring regulatory compliance for chiral purity.

Basic Information

Product Name	(1S,4R) Sertraline Hydrochloride
CAS No.	79896-31-4
Molecular Formula	C17H18Cl3N•HCl
Molecular Weight	403.70 g/mol
Synonyms	(1S,4R)-Sertraline HCl; (1S-cis)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine Hydrochloride; (+)-Sertraline Hydrochloride; Sertraline (1S,4R) Isomer Hydrochloride; Zoloft Intermediate; CP-51974-01; L-Sertraline Hydrochloride
EINECS	Contact for details

Quality Control

Our (1S,4R) Sertraline Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assay and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and specific tests are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.