Description

Rac-trans-Sertraline CAS NO 79836-45-6 is a key stereoisomeric intermediate in the synthesis of the widely prescribed SSRI antidepressant, Sertraline HCl. Its consistent quality and purity are critical for ensuring the efficacy and safety of the final active pharmaceutical ingredient (API). This compound is essential for pharmaceutical R&D laboratories, process chemists, and manufacturers engaged in the development and production of neuropsychiatric therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a critical chiral building block in the multi-step synthesis of Sertraline Hydrochloride.
• Process Research & Development: Used in route scouting, optimization studies, and scale-up processes for antidepressant manufacturing.
• Reference Standard: Serves as an analytical standard for method development and quality control in API production.
• Chemical Synthesis: Employed in organic synthesis for creating novel analogs and conducting structure-activity relationship (SAR) studies.
• Academic Research: Utilized in university and institutional research focusing on neuropharmacology and stereoselective synthesis.

Basic Information

Product Name	Rac-trans-Sertraline
CAS No.	79836-45-6
Molecular Formula	C17H17Cl2N
Molecular Weight	306.23 g/mol
Synonyms	(1R*,4S*)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine; (1RS,4SR)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine; trans-(±)-Sertraline; DL-trans-Sertraline; Rac-trans-Sertraline Free Base; Sertraline trans-racemate
EINECS	Contact for details

Quality Control

Our Rac-trans-Sertraline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the stringent requirements for pharmaceutical intermediates. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	Trans-isomer: ≥ 99.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.