Description

(1R,4R)-Sertraline Hcl is the single enantiomer of the widely used selective serotonin reuptake inhibitor (SSRI), sertraline hydrochloride. This specific stereoisomer is of critical importance for pharmaceutical research and development, particularly in studying structure-activity relationships and developing novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard providers, and manufacturers engaged in the development of enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control testing of sertraline-based drug products.
• Active Pharmaceutical Ingredient (API) Research: Used as a key intermediate or starting material in the research and development of novel enantiopure psychiatric and neurological therapeutics.
• Pharmacological Studies: Essential for preclinical and clinical studies aimed at understanding the specific biological activity, metabolism, and pharmacokinetics of the (1R,4R)-enantiomer.
• Process Chemistry & Synthesis: Employed in developing and optimizing asymmetric synthesis routes for the production of chiral SSRIs.
• Regulatory Submissions: Provides necessary data and materials for regulatory filings (e.g., with FDA, EMA) requiring characterization of individual stereoisomers.

Basic Information

Product Name	(1R,4R)-Sertraline Hcl
CAS No.	79617-98-4
Molecular Formula	C17H18Cl3N•HCl
Molecular Weight	342.69 g/mol (Free base: 306.23)
Synonyms	(1R,4R)-Sertraline Hydrochloride; (1R-cis)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine Hydrochloride; (1R,4R)-Zoloft Impurity; Sertraline Related Compound A (enantiomer); (+)-cis-(1S,4S)-Sertraline HCl (enantiomer); UNII-8K089R168F; Lustral (enantiomer)
EINECS	Contact for details

Quality Control

Our (1R,4R)-Sertraline Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, to ensure identity, potency, and purity meet stringent specifications for research use. Certificates of Analysis (COA) detailing results from HPLC, chiral chromatography, and other relevant tests are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.