Description

13-Hydroxy-14,15-Epoxyeicosa-5,8,11-Trienoic Acid is a specialized eicosanoid derivative, a key intermediate in the biosynthesis of bioactive lipid mediators. This compound is of significant interest for its role in studying inflammatory and cardiovascular signaling pathways, particularly those involving cytochrome P450 metabolites of arachidonic acid. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced life science sectors for drug discovery, biochemical research, and as a reference standard.

Application

• Biochemical Research: A critical reference standard and intermediate for studying the cytochrome P450 (CYP) epoxygenase pathway and its role in vascular biology and inflammation.
• Pharmaceutical Development: Used as a key building block or precursor in the synthesis of novel therapeutic agents targeting cardiovascular diseases and inflammatory disorders.
• Cell Signaling Studies: Employed in vitro and in vivo to investigate the biological activities of epoxy-eicosatrienoic acid (EET) metabolites and their hydroxy derivatives.
• Enzyme Activity Assays: Serves as a substrate or product analog in assays for enzymes like soluble epoxide hydrolase (sEH) to screen for potential inhibitors.
• Metabolomics & Lipidomics: An essential analytical standard for the accurate identification and quantification of oxylipins in complex biological samples via LC-MS/MS.

Basic Information

Product Name	13-Hydroxy-14,15-Epoxyeicosa-5,8,11-Trienoic Acid
CAS No.	79595-80-5
Molecular Formula	C₂₀H₃₂O₄
Molecular Weight	336.47 g/mol
Synonyms	13-Hydroxy-14,15-epoxy-5,8,11-eicosatrienoic acid; 13-Hydroxy-14(15)-epoxy-5Z,8Z,11Z-eicosatrienoic acid; 13-Hydroxy-14,15-EET; 13-OH-14,15-EpETE; 13(S)-Hydroxy-14(S),15(S)-epoxy-5Z,8Z,11Z-eicosatrienoic acid; 13-HETE-Epoxide; 13-Hydroxy-epoxy-eicosatrienoic acid; Arachidonic acid metabolite 13-hydroxy-14,15-epoxide
EINECS	Contact for details

Quality Control

Our 13-Hydroxy-14,15-Epoxyeicosa-5,8,11-Trienoic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.