Description

2-Hydroxy-5-Trifluoromethyl Benzoic Acid is a versatile trifluoromethylated aromatic building block that combines the properties of a benzoic acid with a phenolic hydroxyl group and a highly stable trifluoromethyl substituent. This unique structure makes it a critical intermediate for synthesizing advanced molecules with enhanced lipophilicity, metabolic stability, and bioavailability. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by fine chemical manufacturers producing specialty materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of anti-inflammatory, antimicrobial, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic displays and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Complex Ligand & Catalyst Preparation: Utilized in organic and coordination chemistry to create novel ligands for catalytic systems and metal-organic frameworks (MOFs).
• Dye & Pigment Intermediate: Acts as a starting material for synthesizing specialized fluorinated dyes and pigments with unique color fastness and properties.

Basic Information

Product Name	2-Hydroxy-5-Trifluoromethyl Benzoic Acid
CAS No.	79427-88-6
Molecular Formula	C8H5F3O3
Molecular Weight	206.12 g/mol
Synonyms	5-(Trifluoromethyl)salicylic Acid; 2-Hydroxy-5-(trifluoromethyl)benzoic Acid; 5-Trifluoromethylsalicylic Acid; Salicylic Acid, 5-(Trifluoromethyl)-; Benzoic Acid, 2-hydroxy-5-(trifluoromethyl)-; α-Hydroxy-5-trifluoromethylbenzoic Acid; 2-Hydroxy-α,α,α-trifluoro-p-toluic Acid
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-5-Trifluoromethyl Benzoic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of heat.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.