Description

Cyclosporine CAS NO 79217-60-0 is a potent, cyclic undecapeptide immunosuppressant widely recognized for its selective inhibition of T-lymphocyte activation. This compound is critical for preventing organ transplant rejection and managing autoimmune conditions, offering a targeted mechanism of action with significant therapeutic impact. It is an essential active pharmaceutical ingredient (API) for pharmaceutical manufacturers, research institutions, and compounding facilities developing immunosuppressive therapies.

Application

• Immunosuppressive Drug Formulation: Primary API in oral solutions, soft gelatin capsules, and intravenous formulations for organ transplantation (kidney, liver, heart, lung).
• Autoimmune Disease Treatment: Used in medications for severe psoriasis, atopic dermatitis, rheumatoid arthritis, and other immune-mediated disorders.
• Ophthalmic Preparations: Key ingredient in topical emulsions for treating severe dry eye disease (keratoconjunctivitis sicca) and other ocular surface inflammatory conditions.
• Veterinary Medicine: Applied in veterinary immunosuppressive protocols for managing atopic dermatitis and other immune-related conditions in companion animals.
• Biomedical Research: A vital tool in immunology and cell biology research for studying T-cell function, calcineurin inhibition, and intracellular signaling pathways.
• Drug Delivery System Development: Used in research for novel delivery systems like nanoparticles, liposomes, and micelles to improve bioavailability and reduce side effects.

Basic Information

Product Name	Cyclosporine
CAS No.	79217-60-0
Molecular Formula	C62H111N11O12
Molecular Weight	1202.61 g/mol
Synonyms	Cyclosporin A; Ciclosporin; CsA; OL 27-400; Sandimmune; Cyclosporine A; Cyclosporin; UNII-83HN0GTJ6D; [R-[R*,R*-(E)]]-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-α-amino-butyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl)
EINECS	Contact for details

Quality Control

Our Cyclosporine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) are provided, detailing compliance with relevant pharmacopoeial standards (e.g., USP, EP) for critical parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent moisture absorption. For long-term stability, storage under an inert atmosphere such as nitrogen is recommended.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (Karl Fischer)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	-185° to -195° (c=0.6 in chloroform)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.