Description

R-(-)-Mianserin is the single enantiomer of the tetracyclic antidepressant compound mianserin. This specific stereoisomer is of significant interest in pharmaceutical research and development for studying structure-activity relationships and receptor binding profiles. It serves as a critical chiral intermediate and reference standard for analytical and pharmacological studies. This high-purity material is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for quality control and analytical method development in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: A key chiral building block in the synthesis of enantiomerically pure pharmaceutical compounds.
• Pharmacological Research: Employed in preclinical studies to investigate the specific biological activity and metabolic pathways of the R-(-)-enantiomer.
• Analytical Chemistry: Utilized for calibrating instruments (e.g., HPLC, Chiral Chromatography) and developing enantioselective separation methods.
• Academic & Institutional Research: A vital reagent for universities and research institutes studying neurochemistry, antidepressant mechanisms, and stereochemistry.

Basic Information

Product Name	R-(-)-Mianserin
CAS No.	78684-63-6
Molecular Formula	C18H20N2
Molecular Weight	264.37 g/mol
Synonyms	(R)-(-)-Mianserin; (-)-Mianserin; (R)-Mianserin; 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine, (R)-; (R)-2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine; Levomianserin (unapproved INN); R-(-)-Mianserin Hydrochloride (salt form); CAS 78684-63-6
EINECS	Contact for details

Quality Control

Our R-(-)-Mianserin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assay, identification, and impurity profiling, to ensure it meets stringent specifications for research and development use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.