Description

6-(1-Hydroxy)Benzylpenicillanic Acid S,S-Dioxide is a key β-lactamase inhibitor intermediate and a chemically modified penicillanic acid derivative. This compound matters for its critical role in the synthesis of advanced pharmaceutical agents designed to combat antibiotic resistance. It is primarily needed by research institutions and manufacturers in the pharmaceutical industry, particularly those developing novel β-lactam antibiotic combinations and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of potent β-lactamase inhibitors, such as sulbactam and related compounds, which are used to enhance the efficacy of penicillin and cephalosporin antibiotics.
• Antibiotic Research & Development: Serves as a key scaffold in medicinal chemistry for designing and testing new generations of antibiotics to overcome bacterial resistance mechanisms.
• Biochemical Studies: Used as a reference standard or substrate in enzymatic studies to investigate the kinetics and inhibition of β-lactamase enzymes.
• Process Chemistry: Employed in the scale-up and optimization of manufacturing processes for final active pharmaceutical ingredients (APIs) in the antibiotic class.

Basic Information

Product Name	6-(1-Hydroxy)Benzylpenicillanic Acid S,S-Dioxide
CAS No.	78494-75-4
Molecular Formula	C14H15NO6S
Molecular Weight	325.34 g/mol
Synonyms	(2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide, 6-(Hydroxymethyl)penicillanic acid S,S-dioxide; 6α-(Hydroxymethyl)penicillanic acid 1,1-dioxide; Penicillanic acid, 6-(hydroxymethyl)-, 1,1-dioxide, (2S,5R)-; CP-45,899-1; Sulbactam precursor
EINECS	Contact for details

Quality Control

Our 6-(1-Hydroxy)Benzylpenicillanic Acid S,S-Dioxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your R&D and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.