Description

N(6)-(12-Methylbenzanthracenyl-7-Methyl)Deoxyadenosine is a specialized nucleoside adduct derivative, primarily used as a critical reference standard and research chemical. This compound is essential for studying DNA damage mechanisms, specifically those induced by polycyclic aromatic hydrocarbon (PAH) metabolites, which are significant in toxicology and carcinogenesis research. It is a vital tool for analytical laboratories, academic research institutions, and pharmaceutical R&D departments focused on molecular toxicology, biomarker discovery, and cancer research.

Application

• Biomarker Research: Serves as a definitive standard for quantifying DNA adducts formed by benzanthracene derivatives in biological samples.
• Toxicology Studies: Used to investigate the metabolic activation pathways and genotoxic effects of polycyclic aromatic hydrocarbons (PAHs).
• Analytical Method Development: A key calibrant for advanced analytical techniques such as HPLC-MS/MS, LC-ESI-MS, and 32P-postlabeling assays.
• Cancer Research: Facilitates studies on the molecular initiation of chemical carcinogenesis and the role of specific DNA lesions.
• Environmental Health Science: Enables the assessment of human exposure to environmental carcinogens and associated cancer risk.
• Reference Material Production: Used by manufacturers to produce certified reference materials (CRMs) for quality control in diagnostic and research kits.

Basic Information

Item	Details
Product Name	N(6)-(12-Methylbenzanthracenyl-7-Methyl)Deoxyadenosine
CAS No.	78493-10-4
Molecular Formula	C32H31N5O3
Molecular Weight	533.63 g/mol
Synonyms	N6-(12-Methyl-7-Methylbenz[a]anthracenyl)deoxyadenosine; N6-(12-Methyl-7-MBA)deoxyadenosine; N6-MBA-dA; 7,12-Dimethylbenz[a]anthracene-deoxyadenosine adduct; DNA-7,12-DMBA adduct; N6-(12-Methyl-7-methylbenz[a]anthracenyl)-2'-deoxyadenosine
EINECS	Contact for details

Quality Control

Every batch of N(6)-(12-Methylbenzanthracenyl-7-Methyl)Deoxyadenosine is produced and analyzed under strict quality protocols to ensure identity, purity, and stability. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results from spectroscopic and chromatographic analyses.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and ensure long-term stability. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.