Description

n-(Guanosin-8-Yl)-4-Aminobiphenyl-5'-Monophosphate CAS NO 78281-08-0 is a specific guanosine adduct, a modified nucleotide derivative formed by the covalent binding of a 4-aminobiphenyl metabolite to the C8 position of guanine. This compound is of significant value as a critical biomarker and reference standard in toxicological and carcinogenesis research. It is primarily needed by research institutions, diagnostic laboratories, and pharmaceutical companies engaged in studying DNA damage, chemical carcinogenesis, and developing analytical methods for detecting exposure to aromatic amines.

Application

• Biomarker Standard for DNA Adduct Analysis: Used as a certified reference material in LC-MS/MS, HPLC, and other analytical techniques to quantify exposure to 4-aminobiphenyl and related aromatic amines.
• Toxicological Research: Essential for studying the mechanisms of metabolic activation, DNA binding, and mutagenesis induced by carcinogenic compounds.
• Method Development and Validation: Serves as a critical calibrant for developing highly sensitive and specific assays in forensic, occupational, and environmental health sciences.
• Cancer Etiology Studies: Employed in research investigating the link between specific DNA adducts, genetic damage, and the initiation of cancers such as bladder cancer.
• Quality Control in Diagnostic Kits: Used in the production and QC of diagnostic kits designed to measure DNA damage biomarkers in biological samples.

Basic Information

Product Name	n-(Guanosin-8-Yl)-4-Aminobiphenyl-5'-Monophosphate
CAS No.	78281-08-0
Molecular Formula	C₂₂H₂₃N₆O₈P
Molecular Weight	530.43 g/mol
Synonyms	8-(4-Aminobiphenyl-3-yl)guanosine 5'-monophosphate; N-(Guanosin-8-yl)-4-aminobiphenyl-5'-monophosphate; 4-Aminobiphenyl-C8-guanosine-5'-monophosphate; 4-ABP-C8-Guo-5'-MP; dG-C8-4-ABP-5'-monophosphate; 4-Aminobiphenyl-DNA Adduct (Guanosine Monophosphate); 4-ABP-Guo-5'-MP; Guanine-4-aminobiphenyl adduct 5'-monophosphate
EINECS	Contact for details

Quality Control

Our high-purity biochemicals are produced and handled under strict quality management protocols. Each batch of n-(Guanosin-8-Yl)-4-Aminobiphenyl-5'-Monophosphate undergoes rigorous analytical testing, including HPLC (Purity), LC-MS/MS (Identity Confirmation), and NMR to ensure structural integrity and specified purity levels. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in DMSO, Methanol; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.