Description

Paroxetine Hydrochloride CAS NO 78246-49-8 is the hydrochloride salt of paroxetine, a potent and selective serotonin reuptake inhibitor (SSRI). This active pharmaceutical ingredient (API) is critical for the formulation of antidepressant and anti-anxiety medications, offering high pharmacological efficacy. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of central nervous system (CNS) therapeutics.

Application

• Pharmaceutical API: Primary active ingredient in the manufacture of antidepressant tablets, capsules, and controlled-release formulations.
• Generic Drug Production: Serves as the key component for generic versions of branded SSRI medications.
• Clinical Research: Used in preclinical and clinical studies for investigating new therapeutic applications or dosage forms.
• Reference Standard: Employed as a high-purity standard in analytical laboratories for quality control and method validation.
• Drug Development: Utilized in R&D for formulating new combination therapies or improving drug delivery systems.

Basic Information

Product Name	Paroxetine Hydrochloride
CAS No.	78246-49-8
Molecular Formula	C19H21ClFNO3 • HCl
Molecular Weight	374.29 g/mol (as free base hydrochloride)
Synonyms	Paroxetine HCl; (-)-trans-4-(4'-Fluorophenyl)-3-[(3',4'-methylenedioxy)phenoxy]methyl]piperidine Hydrochloride; BRL 29060A; FG 7051; Aropax 20; Paxil; Seroxat; (3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine Hydrochloride
EINECS	Contact for details

Quality Control

Our Paroxetine Hydrochloride is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to ensure it meets high-purity pharmacopeial standards, including identification, assay, impurity profile, and residual solvent analysis. A Certificate of Analysis (COA) documenting compliance with relevant specifications (e.g., USP, EP, or in-house pharmaceutical grade) is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.