Description

L-Ornithine, [1-14 C] is a carbon-14 labeled derivative of the amino acid L-ornithine, specifically radiolabeled at the 1-carbon position. This compound is a critical tool for metabolic pathway tracing and pharmacokinetic studies, offering researchers a reliable tracer for investigating the urea cycle, polyamine biosynthesis, and other biochemical processes. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and CROs (Contract Research Organizations) engaged in advanced metabolism and drug development studies.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer to study the urea cycle, arginine biosynthesis, and polyamine (putrescine, spermidine, spermine) metabolism in vivo and in vitro.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for tracking the absorption, distribution, metabolism, and excretion (ADME) of new drug candidates that interact with ornithine-related pathways.
• Biochemical Research: Enables precise quantification and visualization of ornithine uptake and utilization in cell culture and animal models.
• Diagnostic Probe Development: Serves as a precursor for synthesizing more complex radiolabeled probes or imaging agents for research purposes.
• Enzyme Activity Assays: Employed in assays to measure the activity of key enzymes such as ornithine decarboxylase (ODC) and ornithine transcarbamylase (OTC).

Basic Information

Product Name	L-Ornithine, [1-14 C]
CAS No.	77882-82-7
Molecular Formula	C5H1214CN2O2
Molecular Weight	~133.1 g/mol (for unlabeled); Specific activity provided on COA.
Synonyms	(2S)-2,5-Diaminopentanoic-1-14C acid; L-Ornithine-1-14C; Ornithine (L-), [1-14C]; [1-14C]-L-Ornithine; (S)-2,5-Diamino[1-14C]pentanoic acid; L-2,5-Diaminopentanoic-1-14C acid
EINECS	Contact for details

Quality Control

Every batch of L-Ornithine, [1-14 C] is manufactured and analyzed under strict quality control protocols to ensure high chemical and radiochemical purity, essential for sensitive research applications. Our quality commitment includes verification of specific activity, radiochemical purity by HPLC, and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, specific activity, and analytical methods is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Handle and dispose of in accordance with all applicable radiation safety regulations and guidelines.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR/HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (1.85-2.22 GBq/mmol) [Custom activities available]
Solvent (if supplied as solution)	Specified on COA (e.g., Water, 0.1M HCl)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.