Description

(2S,4S)-(-)-2,4-Bis(Diphenylphosphino)Pentane CAS NO 77876-39-2 is a high-value, chiral bidentate phosphine ligand, essential for creating asymmetric environments in transition metal catalysis. Its primary value lies in enabling highly enantioselective transformations, which are critical for the efficient synthesis of single-enantiomer pharmaceuticals and fine chemicals. This ligand is particularly sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, a cornerstone reaction in chiral drug intermediate synthesis.
• Asymmetric Cross-Coupling Reactions: Employed in C-C and C-X bond-forming reactions (e.g., Suzuki-Miyaura, Heck) to produce chiral biaryl and other stereogenic compounds.
• Hydroformylation and Hydrocyanation: Used to induce chirality in the addition of CO/H2 or HCN across double bonds, creating chiral aldehydes and nitriles.
• Pharmaceutical Intermediate Synthesis: Critical for constructing complex, single-enantiomer active pharmaceutical ingredients (APIs) for cardiovascular, CNS, and antiviral therapies.
• Agrochemical Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and pesticides for enhanced efficacy and environmental safety.
• Academic and Industrial Research: A vital tool for methodology development in organic synthesis and catalysis within university and corporate R&D laboratories.

Basic Information

Product Name	(2S,4S)-(-)-2,4-Bis(Diphenylphosphino)Pentane
CAS No.	77876-39-2
Molecular Formula	C29H30P2
Molecular Weight	440.50 g/mol
Synonyms	(2S,4S)-(-)-2,4-Bis(diphenylphosphino)pentane; (S,S)-BDPP; (2S,4S)-BDPP; (S,S)-2,4-Bis(diphenylphosphino)pentane; (-)-2,4-Bis(diphenylphosphino)pentane; SKEWPHOS; ChiraPhos; Ligand for asymmetric hydrogenation
EINECS	Contact for details

Quality Control

Every batch of (2S,4S)-(-)-2,4-Bis(Diphenylphosphino)Pentane is manufactured and tested under strict quality management systems to ensure exceptional purity and enantiomeric excess (ee), which are paramount for catalytic performance. Our standard quality commitment includes comprehensive analysis via NMR, HPLC, and specific rotation measurement. Certificates of Analysis (COA) with full analytical data are provided with each shipment to guarantee batch-to-batch consistency and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to prevent oxidation and maintain stability. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Specific Rotation [α]D20	-30° to -34° (c=1 in toluene)
Melting Point	118 - 122 °C
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.