Description

6-Hydroxy-5-Methoxyindole Glucuronide is a specific glucuronide conjugate of a methoxyindole derivative, representing a key metabolite in biochemical pathways. This high-purity reference standard is critical for ensuring analytical accuracy and reproducibility in research and quality control laboratories. It is primarily utilized by pharmaceutical researchers, clinical diagnostic developers, and analytical chemists for method development, validation, and metabolite identification studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of metabolites in drug development and pharmacokinetic studies.
• Clinical Diagnostics: Serves as a calibrator or control in the development of advanced liquid chromatography-mass spectrometry (LC-MS/MS) assays for biomarker detection.
• Biochemical Research: Employed in enzymatic and metabolic pathway studies to investigate glucuronidation processes and phase II metabolism.
• Analytical Method Development: Essential for validating HPLC, UPLC, and LC-MS methods, ensuring specificity, accuracy, and linearity in analytical procedures.
• Quality Control (QC) Testing: Used in QC laboratories of pharmaceutical manufacturers to verify the purity and consistency of related substances or degradation products.

Basic Information

Product Name	6-Hydroxy-5-Methoxyindole Glucuronide
CAS No.	77463-72-0
Molecular Formula	C16H19NO9
Molecular Weight	369.32 g/mol
Synonyms	5-Methoxy-6-hydroxyindole glucuronide; 6-Hydroxy-5-methoxyindole-β-D-glucopyranosiduronic acid; 6-Hydroxy-5-methoxy-1H-indol-3-yl β-D-Glucopyranosiduronic acid; 5-Methoxy-6-hydroxyindole-3-yl β-D-glucuronide; HMIG; 6-OH-5-MeO-indole glucuronide; Indole glucuronide derivative
EINECS	Contact for details

Quality Control

Our 6-Hydroxy-5-Methoxyindole Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific results for all critical parameters. Our quality commitment ensures the material is suitable for use as a high-grade reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture and light. For long-term storage, consider desiccants and under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.