Description

(S)-2-(Tetrahydro-Pyran-2-Yloxy)-Propan-1-Ol is a chiral building block of significant importance in asymmetric synthesis. Its core value lies in its protected diol functionality, which provides a versatile handle for constructing complex molecules with high stereochemical fidelity. This compound is primarily needed by research and development chemists in the pharmaceutical and fine chemical industries for the production of active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of enantiomerically pure drugs, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Asymmetric Synthesis: Used as a starting material or auxiliary in catalytic asymmetric reactions to introduce stereocenters with high enantiomeric excess.
• Natural Product Synthesis: Employed in the total synthesis of complex natural products where its specific stereochemistry and functional groups are required.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Agrochemical Research: Utilized in the development of chiral active ingredients for pesticides and herbicides.
• Material Science: Potential monomer or modifier for creating specialized polymers with chiral properties.

Basic Information

Product Name	(S)-2-(Tetrahydro-Pyran-2-Yloxy)-Propan-1-Ol
CAS No.	76946-21-9
Molecular Formula	C8H16O3
Molecular Weight	160.21 g/mol
Synonyms	(S)-1-(2-Tetrahydropyranyloxy)-2-propanol; (S)-2-(Tetrahydro-2H-pyran-2-yloxy)-1-propanol; (S)-THP-Protected Propylene Glycol; (S)-2-(Oxan-2-yloxy)propan-1-ol; (S)-1-Hydroxy-2-(tetrahydropyran-2-yloxy)propane; (S)-2-(2-Tetrahydropyranyloxy)-1-propanol; (S)-α-Methyl-2-tetrahydropyranyloxymethanol
EINECS	Contact for details

Quality Control

Our (S)-2-(Tetrahydro-Pyran-2-Yloxy)-Propan-1-Ol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.