Description

Equilin 3-o-β-D-Glucuronide is a specific, conjugated metabolite of the natural estrogen equilin, formed by the enzymatic attachment of glucuronic acid. This compound is of significant value as a high-purity reference standard for analytical and research applications, ensuring accurate quantification and metabolic profiling. It is primarily needed by pharmaceutical R&D laboratories, clinical research organizations, and analytical testing facilities focused on steroid hormone metabolism, bioequivalence studies, and the development of sensitive detection methods.

Application

• Pharmaceutical Reference Standard: Serves as a critical calibrant for the quantitative analysis of equilin and its metabolites in biological matrices using LC-MS/MS or HPLC.
• Clinical Research: Used in studies investigating the pharmacokinetics, bioavailability, and metabolic pathways of conjugated equine estrogens (CEE).
• Biomarker Development: Aids in the development and validation of diagnostic assays for hormonal status and metabolic disorders.
• Drug Metabolism & Pharmacokinetics (DMPK): Essential for in vitro and in vivo studies to understand Phase II conjugation (glucuronidation) pathways of steroid hormones.
• Quality Control: Employed in the QC laboratories of API manufacturers to monitor and control impurities related to estrogen conjugates.
• Academic Research: Used in university and institutional labs for fundamental research on estrogen receptor interactions and endocrine-disrupting chemical studies.

Basic Information

Product Name	Equilin 3-o-β-D-Glucuronide
CAS No.	76663-60-0
Molecular Formula	C24H30O9
Molecular Weight	462.49 g/mol
Synonyms	Equilin 3-Glucuronide; 3-Hydroxyequilin 3-β-D-Glucopyranosiduronic Acid; Equilin 3-O-β-D-Glucopyranosiduronic Acid; NSC 113929; 3-Glucuronosylequilin; Equilin Glucuronide; Estra-1,3,5(10),7-tetraene-3,17-diol 3-(β-D-glucopyranosiduronic acid)
EINECS	Contact for details

Quality Control

Our Equilin 3-o-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets high-purity standards suitable for research and analytical use. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.