Description

Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid, 2-Amino-, Endo- (9Ci) is a high-purity, functionalized norbornene derivative that serves as a critical chiral building block in advanced organic synthesis. Its rigid bicyclic structure and reactive amino and carboxylic acid functional groups make it invaluable for constructing complex molecular architectures with precise stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing novel active pharmaceutical ingredients (APIs), chiral ligands, and specialty polymers.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, especially those requiring the rigid norbornene scaffold for biological activity.
• Asymmetric Catalysis: Used in the preparation of chiral ligands and organocatalysts for stereoselective chemical transformations.
• Polymer Science: Serves as a monomer or co-monomer for creating specialty polymers with unique thermal and mechanical properties via ring-opening metathesis polymerization (ROMP) or other techniques.
• Peptidomimetics & Conformationally Restricted Peptides: The bicyclic framework is utilized to induce specific secondary structures in peptide analogs, enhancing stability and bioavailability.
• Material Science Research: Employed in the development of advanced materials, including liquid crystals, coatings, and resins with tailored functionalities.
• Agrochemical Synthesis: Acts as a precursor for creating novel, structurally complex active ingredients for crop protection.

Basic Information

Product Name	Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid, 2-Amino-, Endo- (9Ci)
CAS No.	76637-58-6
Molecular Formula	C9H11NO2
Molecular Weight	165.19 g/mol
Synonyms	2-Amino-2-norbornene-5-carboxylic acid, endo-; endo-2-Aminobicyclo[2.2.1]hept-5-ene-2-carboxylic acid; 5-Norbornene-2-carboxylic acid, 2-amino-, endo-; (1R,2S,4R)-2-Aminobicyclo[2.2.1]hept-5-ene-2-carboxylic acid; endo-2-Amino-5-norbornene-2-carboxylic acid; 2-Azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid derivative; Bicyclo[2.2.1]hept-5-en-2-amine, 2-carboxy-, (1R,2S,4R)-
EINECS	Contact for details

Quality Control

Every batch of Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid, 2-Amino-, Endo- (9Ci) is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding research and scale-up applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (endo- isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.