Description

Levoprotiline is a pharmaceutical intermediate and a stereoisomer of the tricyclic antidepressant maprotiline, distinguished by its specific three-dimensional molecular configuration. This precise stereochemistry is critical for its role in advanced pharmaceutical research and development, particularly in the study of neuropharmacology and the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the development of central nervous system (CNS) therapeutics, process chemistry, and analytical method development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of enantiomerically pure maprotiline and related tricyclic compounds.
• Neuropharmacology Research: Used as a reference standard and active compound in studies targeting norepinephrine reuptake inhibition.
• Process Development & Scale-up: Serves as a critical material for optimizing synthetic routes and purification processes in API manufacturing.
• Analytical Standard: Employed in HPLC, GC, and spectroscopic methods for quality control and method validation.
• Preclinical Studies: Utilized in pharmacological and toxicological evaluations of stereospecific drug candidates.
• Chemical Reference Standard: Provides a high-purity benchmark for identity and purity testing in regulatory submissions.

Basic Information

Product Name	Levoprotiline
CAS No.	76496-68-9
Molecular Formula	C₂₀H₂₃N
Molecular Weight	277.41 g/mol
Synonyms	(1R,2S,4S)-1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine; (-)-Maprotiline; L-Maprotiline; Levoprotilin; (1R,2S,4S)-10,11-Dihydro-2-methyl-5H-dibenzo[a,d]cycloheptene-5,10-imine; (1R,2S,4S)-2-Methyl-1,2,3,4,10,14b-hexahydro-2H-pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
EINECS	Contact for details

Quality Control

Our Levoprotiline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) documenting identity, purity (HPLC), chiral excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The material is moisture-sensitive; ensure the container is kept in a low-humidity environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.