Description

Potassium (2S-Cis)-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate 4,4-Dioxide is a high-purity potassium salt derivative of a penicillanic acid sulfone, serving as a crucial advanced pharmaceutical intermediate. This compound is valued for its role in the synthesis of novel β-lactamase inhibitors, which are essential in combating antibiotic resistance. It is primarily required by pharmaceutical R&D laboratories and manufacturers engaged in the development of next-generation antibacterial agents and combination therapies.

Application

• Key Intermediate in β-Lactamase Inhibitor Synthesis: A critical building block for the production of sulfone-based β-lactamase inhibitors like tazobactam and sulbactam analogs.
• Pharmaceutical Research & Development: Used in medicinal chemistry for designing and testing new antibacterial compounds to overcome multi-drug resistant bacteria.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the scaled-up synthesis of finished dosage forms for antibiotic combinations.
• Process Chemistry & Optimization: Serves as a reference standard and starting material for developing efficient, scalable synthetic routes in pilot plants.
• Academic & Institutional Research: Utilized in university and institutional labs studying bacterial resistance mechanisms and novel inhibition pathways.

Basic Information

Product Name	Potassium (2S-Cis)-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate 4,4-Dioxide
CAS No.	76350-35-1
Molecular Formula	C9H10KNO5S
Molecular Weight	283.35 g/mol
Synonyms	(2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide potassium salt; Potassium 6β-(Hydroxymethyl)-2,2-dimethylpenam-3α-carboxylate 1,1-Dioxide; Potassium Penicillanate 1,1-Dioxide; Potassium Salt of Penicillanic Acid Sulfone; CP-45,899 Potassium Salt; Sulfone Potassium Salt Intermediate; Potassium (2S,5R)-Penicillanate 1,1-Dioxide
EINECS	Contact for details

Quality Control

Our Potassium (2S-Cis)-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate 4,4-Dioxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.