Description

Mildronate CAS NO 76144-81-5 is a synthetic pharmaceutical compound, chemically known as 3-(2,2,2-Trimethylhydrazinium)propionate dihydrate. This active pharmaceutical ingredient (API) is a clinically significant cardioprotective and anti-ischemic agent, primarily used to enhance cellular energy metabolism under conditions of oxygen deficiency. It is essential for manufacturers in the global pharmaceutical industry seeking a reliable, high-purity ingredient for the formulation of cardiovascular and metabolic disorder medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for treating angina pectoris, chronic heart failure, and myocardial infarction.
• Cardioprotective Formulations: Incorporated into tablets, capsules, and injectables designed to protect heart tissue from ischemia and improve exercise tolerance.
• Metabolic Enhancers: Used in drugs aimed at normalizing metabolism in cardiac and brain tissues during hypoxia or insufficient blood flow.
• Neurological Applications: Investigated for use in formulations targeting cerebrovascular disorders and cognitive impairments related to poor cerebral circulation.
• Sports Medicine: Utilized in certain regions in medications intended to improve physical performance and recovery by optimizing energy metabolism.
• Veterinary Pharmaceuticals: Applied in veterinary medicine for similar cardioprotective and metabolic indications in animals.

Basic Information

Product Name	Mildronate
CAS No.	76144-81-5
Molecular Formula	C6H14N2O2 • 2H2O
Molecular Weight	182.20 g/mol (anhydrous basis)
Synonyms	Meldonium; MET-88; 3-(2,2,2-Trimethylhydrazinium)propionate dihydrate; Quaterin; Mildronāts; Trimethylhydrazinium propionate; Mildronate dihydrate; Vazonit
EINECS	Contact for details

Quality Control

Our Mildronate is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical active ingredients. Each batch is subjected to comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis, in compliance with ICH guidelines. A Certificate of Analysis (COA) detailing purity, related substances, and other critical parameters is provided with every shipment to guarantee traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	17.0% - 20.0%
Related Substances (HPLC)	Individual impurity: NMT 0.15% Total impurities: NMT 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 10 ppm
Sulfated Ash	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.