Description

Hyodeoxycholate-6-o-Glucuronide is a conjugated bile acid derivative, specifically the 6-O-glucuronide of hyodeoxycholic acid. This compound is of significant value as a high-purity biochemical reference standard and a critical intermediate in metabolic and pharmacokinetic research. It is primarily needed by pharmaceutical R&D laboratories, analytical service providers, and academic institutions focused on bile acid metabolism, drug development, and biomarker discovery.

Application

• Biochemical Research Standard: Serves as a certified reference material (CRM) for the quantification and identification of bile acid metabolites in biological samples.
• Drug Metabolism & Pharmacokinetics (DMPK): Used as a standard in studies investigating the glucuronidation pathways of bile acids and related steroidal compounds.
• Analytical Method Development: Essential for developing and validating HPLC, LC-MS, and GC-MS methods in clinical and forensic toxicology.
• Enzyme Activity Assays: Employed as a substrate to study the activity of UDP-glucuronosyltransferase (UGT) enzymes.
• Diagnostic Kit Manufacturing: Used in the production of calibrators and controls for diagnostic assays targeting liver function and metabolic disorders.
• Academic Research: A key reagent for fundamental studies on cholestasis, enterohepatic circulation, and gut microbiome interactions.

Basic Information

Product Name	Hyodeoxycholate-6-o-Glucuronide
CAS No.	76060-17-8
Molecular Formula	C30H48O10
Molecular Weight	568.70 g/mol
Synonyms	Hyodeoxycholic Acid 6-O-Glucuronide; 6α-Hyodeoxycholylglucuronide; 3α,6α-Dihydroxy-5β-cholan-24-oic Acid 6-Glucuronide; HDCA-6-G; Hyodeoxycholylglucuronide; NSC 113935; Hyodeoxycholic Acid Glucuronide
EINECS	Contact for details

Quality Control

Our Hyodeoxycholate-6-o-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every lot to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.