Description

(+)-Colchicine CAS NO 75520-89-7 is the biologically active enantiomer of colchicine, a potent tropolone alkaloid derived from plants of the genus *Colchicum*. This high-purity compound is critical for research and development due to its specific and potent tubulin-binding activity, which inhibits microtubule polymerization. It is essential for pharmaceutical R&D, academic research in cell biology, and as a reference standard in analytical laboratories.

Application

• Pharmaceutical Research & Development: Serves as a key active pharmaceutical ingredient (API) intermediate and a reference compound for developing gout and familial Mediterranean fever treatments.
• Biochemical & Cell Biology Research: Used extensively as a microtubule-disrupting agent to study cell division, cytoskeleton dynamics, and mitosis inhibition in vitro.
• Analytical Reference Standard: Employed in HPLC, LC-MS, and NMR for method development, validation, and quality control testing of pharmaceutical products.
• Mechanistic Studies: A vital tool for investigating inflammatory pathways and the role of microtubules in intracellular signaling.
• Preclinical Studies: Utilized in animal models to study pharmacokinetics, efficacy, and toxicity profiles of colchicine-based therapies.

Basic Information

Product Name	(+)-Colchicine
CAS No.	75520-89-7
Molecular Formula	C22H25NO6
Molecular Weight	399.44 g/mol
Synonyms	(+)-Colchicine; (S)-Colchicine; Colchicine; NSC 757; SR 0514; Colchineos; Colgout; Aquacolchin; CI 757; Colchisol; Colcin; Colchicina; Colchicinum; Colchiquim; Colchis; Colsaloid; Condylon; Goutichine; TColc
EINECS	Contact for details

Quality Control

Our (+)-Colchicine is manufactured and tested under strict quality management systems. Each batch is analyzed to meet high-purity standards suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC is provided with every shipment to ensure traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation [α]20/D	-240° to -250° (c=1 in CHCl3)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.