Description

Lesinurad Int is a high-purity pharmaceutical intermediate, identified by CAS number 1533519-85-5. This compound is a critical building block in the synthesis of Lesinurad, a selective uric acid reabsorption inhibitor used in the treatment of hyperuricemia associated with gout. It is essential for pharmaceutical manufacturers and research organizations engaged in the development and production of advanced gout therapies. Our supply ensures consistent quality and reliable availability for global API synthesis.

Application

• Primary Active Pharmaceutical Ingredient (API) Synthesis: Key intermediate in the commercial-scale manufacturing of Lesinurad.
• Research & Development: Used in preclinical and clinical studies for investigating new formulations or combination therapies for gout.
• Process Chemistry & Optimization: Serves as a reference standard and starting material for route scouting and yield improvement studies.
• Generic Drug Manufacturing: A vital raw material for companies producing generic versions of Lesinurad following patent expiry.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs specializing in cGMP-compliant pharmaceutical production.

Basic Information

Product Name	Lesinurad Int
CAS No.	1533519-85-5
Molecular Formula	C₁₇H₁₄BrN₃O₂S
Molecular Weight	404.28 g/mol
Synonyms	2-(5-Bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid; Lesinurad Intermediate; RDEA594 Intermediate; UR-1102 Intermediate; 1-Cyclopropyl-4-(5-mercapto-4H-1,2,4-triazol-4-yl)naphthalene derivative
EINECS	Contact for details

Quality Control

Our Lesinurad Int is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR), to ensure it meets high-grade pharmaceutical standards. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.