Description

n-Deacetyl-1,2,3,10-Demethyl Colchicine Hydrobromide is a high-purity, semi-synthetic derivative of the natural alkaloid colchicine, designed for advanced research and pharmaceutical development. This compound is valued for its specific structural modifications, which are critical for studying structure-activity relationships and developing novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on oncology, anti-inflammatory, and gout-related drug discovery programs.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Biochemical Research: Used as a key intermediate or tool compound in studies investigating tubulin polymerization inhibition, cell cycle arrest, and anti-mitotic mechanisms.
• Preclinical Drug Development: Acts as a precursor or active pharmaceutical ingredient (API) intermediate in the synthesis of next-generation colchicine analogs with potentially improved efficacy and safety profiles.
• Academic Research: Employed in university and institutional labs for fundamental pharmacological and toxicological studies related to microtubule dynamics.

Basic Information

Product Name	n-Deacetyl-1,2,3,10-Demethyl Colchicine Hydrobromide
CAS No.	152242-11-0
Molecular Formula	C20H24BrNO5
Molecular Weight	438.31 g/mol
Synonyms	Demecolcine Hydrobromide; N-Deacetyl-N-methylcolchicine Hydrobromide; Colcemid Hydrobromide; Deacetylcolchicine Hydrobromide; 1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one Hydrobromide; N-Methyl-deacetylcolchicine Hydrobromide; Colecmide HBr
EINECS	Contact for details

Quality Control

Our n-Deacetyl-1,2,3,10-Demethyl Colchicine Hydrobromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.