Description

(R/S)-Colchicine CAS NO 209810-38-8 is a synthetic derivative of the natural alkaloid colchicine, a potent tubulin-binding agent. This compound is a critical reference standard and intermediate for pharmaceutical research and development, particularly in the study of anti-inflammatory and anti-mitotic mechanisms. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and academic sectors who require high-purity chemical entities for drug discovery, analytical method development, and biological studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quality control and validation of analytical methods (e.g., HPLC, LC-MS) in drug manufacturing.
• Biochemical Research: Serves as a key tool compound in cell biology and pharmacology to study microtubule dynamics, cell cycle arrest, and inflammatory pathways like NLRP3 inflammasome inhibition.
• Active Pharmaceutical Ingredient (API) Intermediate: Employed in the synthetic pathways for developing novel colchicine analogs and prodrugs with potential therapeutic applications.
• Preclinical Studies: Utilized in in vitro and in vivo models to investigate efficacy, pharmacokinetics, and toxicology for gout, familial Mediterranean fever (FMF), and cardiovascular diseases.
• Academic & Contract Research: Fundamental for university labs and CROs (Contract Research Organizations) conducting basic research on cytoskeleton function and anti-inflammatory agents.

Basic Information

Product Name	(R/S)-Colchicine
CAS No.	209810-38-8
Molecular Formula	C22H25NO6
Molecular Weight	399.44 g/mol
Synonyms	Colchicine, Racemic; (±)-Colchicine; DL-Colchicine; NSC 757; 7-Acetamido-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one; (S)-Colchicine and (R)-Colchicine mixture; 1,2,3,10-Tetramethoxy-7-acetamido-6,7-dihydro-5H-benzo[a]heptalen-9-one
EINECS	Contact for details

Quality Control

Our (R/S)-Colchicine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, MS), to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) providing batch-specific results is supplied with every order to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	~50:50 R/S mixture
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.