Description

L-Leucine, Ethyl Ester, Labeled With Carbon-14 (9Ci) is a high-specific-activity, isotopically labeled derivative of the essential amino acid L-Leucine. This compound is a critical tool for conducting advanced metabolic, pharmacokinetic, and biochemical tracer studies, providing researchers with a precise and trackable probe. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug discovery and development, where understanding the fate and distribution of compounds within biological systems is paramount.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of new chemical entities and biologics.
• Biochemical Pathway Analysis: Enables the tracing of leucine incorporation into proteins and its role in metabolic pathways such as the mTOR signaling cascade.
• Proteomics Research: Facilitates quantitative protein synthesis and turnover studies in cell cultures and animal models.
• Environmental Fate Studies: Applied in specialized research to track the degradation and environmental impact of amino acid-based compounds.
• Internal Standard for Mass Spectrometry: Serves as a labeled internal standard in LC-MS/MS and GC-MS analyses for accurate quantification of L-Leucine and related metabolites.
• Preclinical Imaging: Supports autoradiography and other imaging techniques to visualize compound localization in tissues.

Basic Information

Product Name	L-Leucine, Ethyl Ester, Labeled With Carbon-14 (9Ci)
CAS No.	75023-21-1
Molecular Formula	C8H17*NO2 (*denotes 14C label)
Molecular Weight	~175.2 g/mol (unlabeled)
Synonyms	L-Leucine ethyl ester; Ethyl L-leucinate; (S)-2-Amino-4-methylpentanoic acid ethyl ester; Leucine ethyl ester; H-Leu-OEt; [14C]-L-Leucine ethyl ester; [Ethyl-1-14C]-L-Leucine ethyl ester; NSC 334365
EINECS	Contact for details

Quality Control

Every batch of our Carbon-14 labeled L-Leucine Ethyl Ester is manufactured and tested under strict quality systems to ensure radiochemical purity, specific activity, and chemical identity. Production adheres to cGMP guidelines where applicable for radioactive pharmaceuticals. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for radiochemical purity (by HPLC), specific activity, chemical purity, and solvent content. Our quality commitment ensures data integrity for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is moisture-sensitive (hygroscopic). For long-term storage, keep under inert atmosphere. Follow all applicable local and international regulations for the safe handling and storage of radioactive materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution or solid
Identification (IR / NMR)	Conforms to structure
Radiochemical Purity (HPLC)	≥ 98%
Specific Activity	~9 Ci/mmol (Contact for exact value)
Chemical Purity (HPLC)	≥ 95%
Solvent (if supplied as solution)	Ethanol or other specified solvent
Radioactive Concentration	As per customer requirement

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.